{"id":991,"date":"2017-12-19T17:06:34","date_gmt":"2017-12-19T09:06:34","guid":{"rendered":"https:\/\/www.agrinoon.com\/agriculture\/?p=991"},"modified":"2017-12-19T17:06:34","modified_gmt":"2017-12-19T09:06:34","slug":"gene-editing-will-boost-crop-yields","status":"publish","type":"post","link":"https:\/\/www.agrinoon.com\/agriculture\/2017\/12\/19\/gene-editing-will-boost-crop-yields\/","title":{"rendered":"How gene editing will boost crop yields"},"content":{"rendered":"<div class=\"post-content\">Keywords:\u00a0Gene editing, Crop yields, GMO<\/div>\n<div id=\"detailbox\" class=\"post-content\">On the surface, a light switch and gene editing have as much in common as a linebacker does with a ballerina.<\/p>\n<\/div>\n<div class=\"post-content\">Dig a bit deeper, though. \u201cIn a very simple way, the main application of gene editing is like flipping a light switch on and off,\u201d says Federico Tripodi, chief executive officer of Calyxt, a New Brighton, Minnesota, agricultural technology firm.<\/p>\n<\/div>\n<div class=\"post-content\">Gene editing is a group of technologies used to turn on or off or alter material at specific locations in a crop\u2019s genome (an organism\u2019s genetic material). Want to rid a crop of a disease? Flick off a switch. Want to unlock a yield-enhancing characteristic? Flick on a switch.<\/p>\n<\/div>\n<div class=\"post-content\">Scientists see this technology as transformational, akin to when genetically modified corn and soybeans hit the market in the 1990s. It doesn\u2019t carry the baggage of genetically modified organism (GMO) technology, either.<\/p>\n<\/div>\n<div class=\"post-content\">\u201c<strong>With GMOs, we introduce a foreign material into the plant,<\/strong>\u201d says Adrian Percy, global head of research and development for Bayer Crop Science. \u201c<strong>With gene editing, we make changes to the existing genome, rather than with foreign genetic material<\/strong>.\u201d<\/p>\n<\/div>\n<div class=\"post-content\">Gene editing may be a more palatable technology for consumers.<\/p>\n<\/div>\n<div class=\"post-content\">\u201cWhen we talk about inserting nonnative genes, consumers get apprehensive,\u201d says Richard Wilkins, a Greenwood, Delaware, farmer and chairman of the American Soybean Association. \u201cThey don\u2019t have as much apprehension about changing and editing existing genes in a plant.\u201d<\/p>\n<\/div>\n<div class=\"post-content\">Farmers quickly gleaned agronomic benefits from GMO technology. Consumers? Not so much. Gene editing could change that, since it\u2019s keying consumer-friendly products that nix trans fats, boost complex carbohydrates and fiber, and eliminate food allergies.<\/p>\n<\/div>\n<div class=\"post-content\">\u201cIf this technology helps people live a better life, I think we can turn it (consumer acceptance) in the right direction,\u201d says Chip Bowling, a Newburg, Maryland, farmer and past president of the National Corn Growers Association.<\/p>\n<div><\/div>\n<h4><strong><br \/>\nHOW IT WORKS<\/strong><\/h4>\n<\/div>\n<div class=\"post-content\">An organism\u2019s genetic information (whether it be plant, animal, or human) is encoded by DNA, says Brad Fabbri, chief science officer for TechAccel, a Shawnee Mission, Kansas, agricultural venture and technology development firm.<\/p>\n<\/div>\n<div class=\"post-content\">A strand of DNA contains four nucleotide bases: adenine, cytosine, guanine, and thymine. (Also known as letters, these bases are referred to as A, C, G, and T.) These letters and their order actually spell out an organism\u2019s genetic code. Changing letter order can alter this code, says Fabbri.<\/p>\n<\/div>\n<div class=\"post-content\">These changes have occurred naturally for eons through a process called mutagenesis.<\/p>\n<\/div>\n<div class=\"post-content\">\u201cIt can happen randomly,\u201d says Fabbri. \u201cWalking around the beach and being hit by cosmic rays can change DNA.\u201d<\/p>\n<\/div>\n<div class=\"post-content\">Plant breeders also have used mutagenesis to spur changes in plant varieties. That often takes years, though. \u201cWith CRISPR-Cas (a gene-editing technology), the time can be cut down to six months, says Dean Bushey, Bayer Crop Science global regulatory manager for research.<\/p>\n<\/div>\n<div class=\"post-content\"><\/div>\n<div class=\"post-content\"><\/div>\n<div class=\"post-content\">Gene editing eliminates the randomness and imprecision that sometimes results when a transgenic technology is used to insert a trait in the genome. The accuracy incurred by gene editing vs. GMO technology is akin to that of a high-powered rifle over a shotgun.<\/p>\n<p>\u201cOne of the differentiators of genetic technology (compared with GMO technology) is the amount of specificity we can achieve,\u201d says Tripodi. \u201cWe identify a genetic sequence only involved with that gene and not the rest of the genome. To get sulfonylurea (<a class=\"anchor\" href=\"http:\/\/www.agropages.com\/CompanyDirectory\/CList-11-----1.htm\" target=\"_blank\" rel=\"noopener noreferrer\">herbicide<\/a> ) resistance in canola, we have made two- to three-letter changes in the codes for that gene.\u201d<br \/>\n<strong><br \/>\n<\/strong><\/div>\n<div class=\"post-content\"><strong>Typically, genetically modified products take 13 years and around $130 million to commercialize, adds Tripodi.<\/p>\n<p><\/strong><\/div>\n<div class=\"post-content\"><strong>\u201cWe can develop products (with gene editing) in half the time,\u201d he says.<\/strong><\/p>\n<div><\/div>\n<h4><strong><br \/>\nPRECISE CUTS<\/strong><\/h4>\n<\/div>\n<div class=\"post-content\">Scientists can do this using various tools that slice, dice, and edit the plant\u2019s genome. They include:<\/p>\n<ul>\n<li><strong>TALEN<\/strong><\/li>\n<li><strong>Meganucleases<\/strong><\/li>\n<li><strong>Zinc finger nucleases<\/strong><\/li>\n<li><strong>CRISPR-Cas<\/strong><\/li>\n<li><strong>Oligonucleotide-directed mutagenesis (ODN)<\/strong>. Cibus\u2019s Rapid Trait Development System and KeyGene\u2019s KeyBase are variants of the same basic oligonucleotide-directed mutagenesis technology, notes Fabbri.<\/li>\n<li><strong>Engineered meganucleases<\/strong><\/li>\n<\/ul>\n<\/div>\n<div class=\"post-content\">\u201cYou can think of those tools as scissors that make a precise cut in the DNA,\u201d says Tripodi. This can either deactivate or activate the specific gene, he says.<\/p>\n<\/div>\n<div class=\"post-content\">\u201cThe cuts trigger the cell\u2019s own DNA repair system to make modifications,\u201d adds Fabbri. It\u2019s similar to natural mutation (such as one that occurs from cosmic rays or ultraviolet rays from sunlight) that damages DNA and then spurs repair, he says.<\/p>\n<\/div>\n<div class=\"post-content\">All have different characteristics.The TALEN technology is proprietary to Calyxt. Company scientists say its precision helps prevent unnecessary genome cuts.<\/p>\n<\/div>\n<div class=\"post-content\">Companies like DuPont Pioneer use the CRISPR-Cas9 enzyme, which is akin to a molecular scissors.<\/p>\n<\/div>\n<div class=\"post-content\">\u201cWe can make a snip here, make a snip there, and make targeted changes,\u201d says Bob Meeley, DuPont Pioneer senior research scientist. \u201cLike a word processor, the technology can replace, edit, and change spellings.\u201d<\/p>\n<\/div>\n<div class=\"post-content\">Like TALEN, the CRISPR-Cas9 enzyme can also edit up five or more different genes in the same genome.<\/p>\n<\/div>\n<div class=\"post-content\">\u201cIn the past, just one gene could be done at a time. This is the first technology that lets us look at up to five genes or more,\u201d says Bushey.<\/p>\n<div><\/div>\n<h4><strong>LIMITS<\/strong><\/h4>\n<\/div>\n<div class=\"post-content\">Gene editing isn\u2019t the technology to end all technologies, though.<\/p>\n<\/div>\n<div class=\"post-content\">Although scientists have mapped many crop genomes, they don\u2019t know how many genes in the genome function.<\/p>\n<\/div>\n<div class=\"post-content\">\u201cWe have to know what genes do before we can edit them,\u201d says Bushey. \u201cWe know the sequence of the genes, but we have to know how they work.\u201d<\/p>\n<\/div>\n<div class=\"post-content\">Another hurdle: Gene editing only can transform a crop if an inherent quality is already present. For example, protection from a viral disease will work only if it\u2019s already present in a gene.<\/p>\n<\/div>\n<div class=\"post-content\">For that reason, Bushey doesn\u2019t see GMO technology going away anytime soon.<\/p>\n<\/div>\n<div class=\"post-content\">For example, gene editing still can\u2019t churn out insect resistance as well as genetically modified Bt corn, says Meeley. \u201cFor things like drought resistance<\/div>\n<div class=\"post-content\">that already may be present in the plant, it may work out well,\u201d he adds.<\/p>\n<\/div>\n<div class=\"post-content\">Technologies will also improve. \u201cMore and deeper genomic knowledge will give us more precision in the long run,\u201d says Meeley.<\/p>\n<div><\/div>\n<h4><strong>REGULATORY PASS?<\/strong><\/h4>\n<\/div>\n<div class=\"post-content\">So far, it\u2019s likely that gene-edited seeds will dodge the long regulatory process endured by genetically modified organisms (GMOs).<\/p>\n<\/div>\n<div class=\"post-content\">\u201cUSDA responded in April 2016 that gene editing will not be regulated like a GMO,\u201d says Morrie Bryant, DuPont Pioneer senior marketing manager. \u201cWith GMOs, you bring in genetic material from other species. That is not what we are doing.\u201d<\/p>\n<\/div>\n<div class=\"post-content\">\u201cThat will reduce cost of regulatory compliance dramatically, allowing smaller players to compete,\u201d says John Goldberg, founder of Science Based Strategies, a Washington, D.C., consulting firm.<\/p>\n<\/div>\n<div class=\"post-content\">Minimal regulation could team with inexpensive technology costs to allow gene-editing technology to proliferate among numerous parties. A CRISPR-Cas9 kit can now be ordered online for around $110, says Dean Bushey, Bayer Crop Science global regulatory manager for research.<\/p>\n<\/div>\n<div class=\"post-content\">\u201cCRISPR-Cas is so cheap and easy to work with,\u201d adds Brad Fabbri, chief science officer for TechAccel. \u201cLiterally, smart high schoolers can use the technology. It has lowered the bar as to how much sophistication it takes to use it.\u201d<\/p>\n<\/div>\n<div class=\"post-content\">\u201cGene editing provides a unique opportunity to democratize access to technology in much the same way as what we see with digital tools,\u201d adds Robb Fraley, Monsanto chief technology officer.<\/p>\n<div><\/div>\n<h4><strong>CONSUMER SAY<\/strong><\/h4>\n<\/div>\n<div class=\"post-content\">Regulation and availability of the technology are only half the battle, though. Consumers have to be persuaded that food products produced by gene editing are safe.<\/p>\n<\/div>\n<div class=\"post-content\"><\/div>\n<div class=\"post-content\">\u201cThere is a tremendous desire to learn from past GMO controversy,\u201d says Bob Meeley, DuPont Pioneer senior research scientist. \u201cWe want to listen to consumers and understand their concerns so this is not just dropped on them.\u201d<\/p>\n<\/div>\n<div class=\"post-content\">Companies will have to be transparent with technology, says Fabbri. \u201cConsumers have a valid right to know what is in their food and that it is safe,\u201d he says.<\/p>\n<\/div>\n<div class=\"post-content\">Producing foods that appeal to consumers also is key.<\/p>\n<\/div>\n<div class=\"post-content\">\u201cIf companies can make products like a potato chip or french fry with less unhealthy components, I think that is where the industry needs to go,\u201d says Fabbri. \u201cThis could help shift opinion with consumers concerned about their health and their family\u2019s health.\u201d<\/p>\n<div><\/div>\n<h4><strong>CHANGING THE GENETIC CODE<\/strong><\/h4>\n<\/div>\n<div class=\"post-content\">Cibus, a San Diego trait-development company, uses its Rapid Trait Development System (RTDS) to boost a plant\u2019s tolerance to disease, herbicide, or environmental stressors. Cibus officials say it does this by changing just one or several letters in the genetic code.<\/p>\n<\/div>\n<div class=\"post-content\">Cibus officials point out that all cells have sophisticated systems that proofread DNA and correct copying errors that are made as cells divide. RTDS works by guiding this natural repair system to make precise spelling changes in the genetic code. This produces the intended beneficial traits, say company officials.<\/p>\n<\/div>\n<div class=\"post-content\">The surgical precision of RTDS helps accelerate conventional plant breeding timelines to deliver the improved varieties much sooner, points out Cibus officials.<\/p>\n<div><\/div>\n<h4><strong>WHAT&#8217;S COMING UP<\/strong><\/h4>\n<\/div>\n<div class=\"post-content\">There are a number of gene-edited crops that are slated to hit the market in the near future. Here are some of them.<\/p>\n<ul>\n<li><strong>High-oleic soybeans<\/strong>. Calyxt is devising a high-oleic soybean slated to debut in 2018. These soybeans appeal to consumers because they\u2019re healthier than many other cooking or baking oils, say industry officials. They contain zero trans fats and have an oleic content exceeding 75%. This level is similar to olive oil, a healthy cooking oil. High-oleic soybean oil also has two to three times longer the fry and shelf life that commodity soybean oil has.<\/li>\n<li><\/li>\n<li>Calyxt is also developing herbicide tolerance in wheat using gene editing. On the consumer side, the company is researching products like wheat varieties with reduced gluten and increased fiber content.<\/li>\n<li><\/li>\n<li><strong>Waxy corn<\/strong>. DuPont Pioneer plans to release improved waxy corn hybrids in 2019 or 2020. \u201cWe are leaders in the waxy corn market,\u201d says Bob Meeley, DuPont Pioneer senior research scientist. \u201cWe know its biology, and we can do it broadly and quickly.\u201d<\/li>\n<li><\/li>\n<li>Cibus also has upcoming products using its Rapid Trait Development System technology that include:<\/li>\n<li><\/li>\n<li><strong>Glyphosate-tolerant flax<\/strong>. It is set to debut in several years.<\/li>\n<li><strong>Two nontransgenic herbicide-tolerant traits for rice.<\/strong><\/li>\n<li><strong>Disease-resistant potatoes<\/strong>. These resist phytophthora late blight, which caused the Irish potato famine of the 1840s.<\/li>\n<\/ul>\n<\/div>\n<div class=\"post-meta\"><b>Source:\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0<\/b>agriculture.com<\/div>\n","protected":false},"excerpt":{"rendered":"<p>Keywords:\u00a0Gene editing, Crop yields, GMO On the surface, a light switch and gene editing have as much in common as a linebacker does with a ballerina. Dig a bit deeper, though. \u201cIn a very simple way, the main application of gene editing is like flipping a light switch on and off,\u201d says Federico Tripodi, chief&hellip; <a class=\"more-link\" href=\"https:\/\/www.agrinoon.com\/agriculture\/2017\/12\/19\/gene-editing-will-boost-crop-yields\/\">Continue reading <span class=\"screen-reader-text\">How gene editing will boost crop yields<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[17],"tags":[],"class_list":["post-991","post","type-post","status-publish","format-standard","hentry","category-industry-news","entry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v21.6 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>How gene editing will boost crop yields - agrinoon<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.agrinoon.com\/agriculture\/2017\/12\/19\/gene-editing-will-boost-crop-yields\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"How gene editing will boost crop yields - agrinoon\" \/>\n<meta property=\"og:description\" content=\"Keywords:\u00a0Gene editing, Crop yields, GMO On the surface, a light switch and gene editing have as much in common as a linebacker does with a ballerina. 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Dig a bit deeper, though. \u201cIn a very simple way, the main application of gene editing is like flipping a light switch on and off,\u201d says Federico Tripodi, chief&hellip; Continue reading How gene editing will boost crop yields","og_url":"https:\/\/www.agrinoon.com\/agriculture\/2017\/12\/19\/gene-editing-will-boost-crop-yields\/","og_site_name":"agrinoon","article_published_time":"2017-12-19T09:06:34+00:00","author":"admin","twitter_card":"summary_large_image","twitter_misc":{"Written by":"admin","Est. reading time":"8 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/www.agrinoon.com\/agriculture\/2017\/12\/19\/gene-editing-will-boost-crop-yields\/","url":"https:\/\/www.agrinoon.com\/agriculture\/2017\/12\/19\/gene-editing-will-boost-crop-yields\/","name":"How gene editing will boost crop yields - agrinoon","isPartOf":{"@id":"https:\/\/www.agrinoon.com\/agriculture\/#website"},"datePublished":"2017-12-19T09:06:34+00:00","dateModified":"2017-12-19T09:06:34+00:00","author":{"@id":"https:\/\/www.agrinoon.com\/agriculture\/#\/schema\/person\/535254a24a4e1135afec5bcc244a5a8c"},"breadcrumb":{"@id":"https:\/\/www.agrinoon.com\/agriculture\/2017\/12\/19\/gene-editing-will-boost-crop-yields\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/www.agrinoon.com\/agriculture\/2017\/12\/19\/gene-editing-will-boost-crop-yields\/"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/www.agrinoon.com\/agriculture\/2017\/12\/19\/gene-editing-will-boost-crop-yields\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/www.agrinoon.com\/agriculture\/"},{"@type":"ListItem","position":2,"name":"How gene editing will boost crop yields"}]},{"@type":"WebSite","@id":"https:\/\/www.agrinoon.com\/agriculture\/#website","url":"https:\/\/www.agrinoon.com\/agriculture\/","name":"agrinoon","description":"","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/www.agrinoon.com\/agriculture\/?s={search_term_string}"},"query-input":"required name=search_term_string"}],"inLanguage":"en-US"},{"@type":"Person","@id":"https:\/\/www.agrinoon.com\/agriculture\/#\/schema\/person\/535254a24a4e1135afec5bcc244a5a8c","name":"admin","image":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/www.agrinoon.com\/agriculture\/#\/schema\/person\/image\/","url":"https:\/\/secure.gravatar.com\/avatar\/727d38bbce271274ba21a10196f68d0e97dc7f36482cf2ddd1a056ba4ac20386?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/727d38bbce271274ba21a10196f68d0e97dc7f36482cf2ddd1a056ba4ac20386?s=96&d=mm&r=g","caption":"admin"},"sameAs":["http:\/\/s691948366.onlinehome.us\/demo\/agrinoon"],"url":"https:\/\/www.agrinoon.com\/agriculture\/author\/admin\/"}]}},"_links":{"self":[{"href":"https:\/\/www.agrinoon.com\/agriculture\/wp-json\/wp\/v2\/posts\/991","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.agrinoon.com\/agriculture\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.agrinoon.com\/agriculture\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.agrinoon.com\/agriculture\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.agrinoon.com\/agriculture\/wp-json\/wp\/v2\/comments?post=991"}],"version-history":[{"count":0,"href":"https:\/\/www.agrinoon.com\/agriculture\/wp-json\/wp\/v2\/posts\/991\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.agrinoon.com\/agriculture\/wp-json\/wp\/v2\/media?parent=991"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.agrinoon.com\/agriculture\/wp-json\/wp\/v2\/categories?post=991"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.agrinoon.com\/agriculture\/wp-json\/wp\/v2\/tags?post=991"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}