{"id":1307,"date":"2018-03-28T17:05:52","date_gmt":"2018-03-28T09:05:52","guid":{"rendered":"https:\/\/www.agrinoon.com\/agriculture\/?p=1307"},"modified":"2018-03-28T17:05:52","modified_gmt":"2018-03-28T09:05:52","slug":"scientists-made-breakthrough-battle-rice-blast","status":"publish","type":"post","link":"https:\/\/www.agrinoon.com\/agriculture\/2018\/03\/28\/scientists-made-breakthrough-battle-rice-blast\/","title":{"rendered":"Scientists made breakthrough in battle against rice blast"},"content":{"rendered":"
Keywords: rice<\/div>\n
An international team led by the University of Exeter showed that chemical genetic inhibition of a single protein in the fungus stops it spreading inside a rice leaf \u2013 leaving it trapped within a single plant cell.\n<\/div>\n
The finding is a breakthrough in terms of understanding rice blast, a disease that is hugely important in terms of global food security.\n<\/div>\n
However, the scientists caution that this is a \u201cfundamental\u201d discovery \u2013 not a cure that can yet be applied outside the laboratory.\n<\/div>\n
The research<\/a> <\/span>revealed how the fungus can manipulate and then squeeze through natural channels (called plasmodesmata) that exist between plant cells.\n<\/div>\n
\u201cThis is an exciting breakthrough because we have discovered how the fungus is able to move stealthily between rice cells, evading recognition by the plant immune system,\u201d said senior author Professor Nick Talbot FRS, of the University of Exeter.\n<\/div>\n
\u201cIt is clearly able to suppress immune responses at pit fields (groups of plasmodesmata), and also regulate its own severe constriction to squeeze itself through such a narrow space.\n<\/div>\n
\u201cAnd all this is achieved by a single regulatory protein. It\u2019s a remarkable feat.\u201d\n<\/div>\n
Rice blast threatens global food security, destroying enough rice each year to feed 60 million people.\n<\/div>\n
It spreads within rice plants by invasive hyphae (branching filaments) which break through from cell to cell.\n<\/div>\n
In their bid to understand this process, the researchers used chemical genetics to mutate a signalling protein to make it susceptible to a specific drug.\n<\/div>\n
The protein, PMK1, is responsible for suppressing the rice\u2019s immunity and allowing the fungus to squeeze through pit fields \u2013 so, by inhibiting it, the researchers were able to trap the fungus within a cell.\n<\/div>\n
This level of precision led the team to discover that just one enzyme, called a MAP kinase, was responsible for regulating the invasive growth of rice blast.\n<\/div>\n
The research team hope this discovery will enable them to identify targets of this enzyme and thereby determine the molecular basis of this devastating disease.\n<\/div>\n
The research was led by Dr Wasin Sakulkoo, who recently received his PhD from Exeter.\n<\/div>\n
Dr Sakulkoo is a Halpin Scholar, a programme initiated by the generosity of Exeter alumni Les and Claire Halpin, which funds students from rice-growing regions of the world to study with Professor Talbot\u2019s research group.\n<\/div>\n
Dr Sakulkoo is from Thailand, and has returned home to a new position in industry following graduation.\n<\/div>\n
The project involved state-of-the-art live cell imaging procedures pioneered at Exeter by postdoctoral fellow Dr George Littlejohn, who is now a lecturer at Plymouth University, and electron microscopy specialists Christian Hacker and Ana Correia.\n<\/div>\n
The research was also an international effort involving collaborators from Kansas State University, Dr Barbara Valent and Dr Ely Oliviera Garcia, and former Marie Curie Fellow Dr Miriam Oses-Ruiz.\n<\/div>\n
The work was funded by the European Research Council (ERC).\n<\/div>\n
Professor Talbot said: \u201cInternational collaboration is central to our research and vital to keep us operating at the frontiers of understanding.\n<\/div>\n
\u201cSupport from the ERC was pivotal to this project, as was the generous support of Claire Halpin, who has continued to support my research work and believe in the power of fundamental research and retraining to solve one of the world\u2019s most devastating diseases.\u201d\n<\/div>\n
The paper, published in the journal Science, is entitled: \u201cA single fungal MAP kinase controls plant cell-to-cell invasion by the rice blast fungus.\u201d<\/div>\n
\n
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Source<\/strong>: University of Exeter<\/a><\/span><\/div>\n<\/div>\n
<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

Keywords: rice An international team led by the University of Exeter showed that chemical genetic inhibition of a single protein in the fungus stops it spreading inside a rice leaf \u2013 leaving it trapped within a single plant cell. The finding is a breakthrough in terms of understanding rice blast, a disease that is hugely… Continue reading Scientists made breakthrough in battle against rice blast<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[17],"tags":[],"class_list":["post-1307","post","type-post","status-publish","format-standard","hentry","category-industry-news","entry"],"yoast_head":"\nScientists made breakthrough in battle against rice blast - agrinoon<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.agrinoon.com\/agriculture\/2018\/03\/28\/scientists-made-breakthrough-battle-rice-blast\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Scientists made breakthrough in battle against rice blast - agrinoon\" \/>\n<meta property=\"og:description\" content=\"Keywords: rice An international team led by the University of Exeter showed that chemical genetic inhibition of a single protein in the fungus stops it spreading inside a rice leaf \u2013 leaving it trapped within a single plant cell. 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